Activated Dissolved Oxygen: A Powerful Adjunct to Traditional Oxygen Therapy

The effectiveness of oxygen therapy is best measured by its ability to deliver oxygen in a minimally invasive manner directly in dissolved form to the cellular level. Activated dissolved oxygen is an innovative enhancement to traditional oxygen therapy that significantly boosts oxygen availability in the body by supplying it in a highly bioavailable form.

A strong immune system depends on adequate oxygenation. Emerging technologies now offer a safer and non-invasive alternative. By enriching the air used in traditional oxygen therapy with aerosolized dissolved oxygen molecules, these methods can increase oxygen delivery directly to tissues. This approach complements the body’s natural hemoglobin-based oxygen transport system and enhances lung oxygen uptake. It can support cellular function, accelerate recovery, improve metabolic activity, and potentially reverse symptoms associated with low oxygenation. Under normal respiration, oxygen enters the body as a gas through the lungs, where it crosses the alveolar membrane into the bloodstream.

Approximately 98% of this oxygen binds to hemoglobin in red blood cells; only around 2% exists in dissolved form, readily available for tissue absorption. This unbound oxygen resides in plasma and interstitial fluids. Hemoglobin must continuously release dissolved oxygen into the interstitial fluid to maintain adequate levels for cellular uptake, regulated by a pressure gradient system.

Dissolved oxygen therapy provides an auxiliary method for enhancing oxygen delivery. Unlike traditional therapies that rely entirely on hemoglobin, this approach introduces unbound, bioactive oxygen molecules directly into the body. It works by using humidified or aerosolized air enriched with water treated with an oxygen-activating, non-toxic electrolytic solution of oxygen species (ESOS). This formulation generates breathable, dissolved oxygen metabolites that increase the oxygen concentration available for absorption. Factors such as oxygenating agent concentration, inhalation method, and treatment duration must be considered to optimize efficacy.

Wetway’s Amazing O and Amazing Soak products are ESOS formulations that produce six reactive oxygen species (ROS) in an aqueous solution. These energized oxygen molecules share oxidant and antioxidant roles, creating a high redox potential and a lasting regenerative effect that contributes to cellular respiration and therapeutic action.

Dissolved oxygen therapy can:

• Enhance oxygen absorption by the lungs.
• Bypass the circulatory system to deliver oxygen directly to tissues.
• Inactivate infectious agents through cell lysis.
• Reduce inflammation.
• Supply unbound oxygen to the interstitial fluid through ionic exchange.

Although partially limited by respiratory capacity, this therapy enhances the first metabolic pass (oxygen transfer in the lungs) and bypasses the second pass (circulation), delivering oxygen efficiently without requiring metabolic energy.

Transdermal Application of Dissolved Oxygen

ESOS supports another promising application method: transdermal oxygen delivery. Since water makes up 60–90% of cellular content and surrounds the plasma membranes—including those of skin cells—topical application of dissolved oxygen can be highly effective. When the skin is in wet contact with dissolved oxygen, passive diffusion allows oxygen to move across the dermal layers. This process, known as osmosis, transports oxygen from areas of high oxygen concentration to areas of lower concentration, ultimately reaching oxygen-deprived tissues. Once absorbed, the oxygen continues to move along the body’s internal energy gradients to support cellular respiration and metabolic activity.

Comparing Transdermal and Respiratory Oxygenation

While respiration brings oxygen to the interstitial fluid through a complex pathway—nasal intake, lung absorption, and hemoglobin transport—transdermal oxygen reaches the same endpoint via a much simpler route. For cells, the delivery method is irrelevant; what matters is the availability of oxygen in the interstitial fluid. Transdermal oxygenation delivers therapeutic doses of bioavailable oxygen more directly and, in some cases, more efficiently than traditional methods such as hyperbaric oxygen or CPAP therapy. Transdermal delivery can be achieved through various means, including soaking, misting, spraying, fogging, or steaming a solution of active oxygen metabolites. Importantly, this approach can be safely used at home when proper protocols are followed. Individuals with existing health conditions should consult with their healthcare provider before use.